Membranous nephropathy: thinking through the therapeutic options
نویسندگان
چکیده
منابع مشابه
Idiopathic Membranous Nephropathy: Diagnostic and Therapeutic Challenges.
BACKGROUND In adults, membranous nephropathy (MN) is a major cause of nephrotic syndrome. While a majority of cases of MN are idiopathic, secondary forms can be seen in the setting of autoimmune disease, neoplasia, infection, and after being exposed to certain therapeutic agents. Both human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections could cause MN. However, the effect o...
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A forty-three year old female applied for a $200,000 ten year decreasing term policy. She admitted a history of "kidney disorder" on the application. She was not being treated or having any symptoms but stated that she was under observation. A routine paramed exam showed height 5’4", weight 140 lbs, and blood pressure 110/70. The BCP was normal. The HOS showed 210 mg/dl proteinuria. A reflex de...
متن کاملMembranous Nephropathy
Forty-one patients with a nephrotic syndrome and biopsy-proven membranous nephropathy were administered a 3 to 6-month course of cyclosporine (CsA; 4 to 5 mg/kg per day). Differential solute clearances were used to evaluate glomerular function before and after therapy. CsA lowered median proteinuria by 56%, from 7.3 to 3.2 g/24 h (P < 0.0001). Corresponding mean increments in serum albumin, imm...
متن کاملMembranous Nephropathy
Membranous nephropathy (MN), a very common cause of nephrotic syndrome, is a glomerulopathy defined histopathologically by the presence of immune complexes on the extracapillary side of the glomerular basement membrane (GBM). Idiopathic membranous nephropathy (IMN) is an antibody-mediated glomerular disease with no defined etiology, histologically characterized by uniform thickening of glomerul...
متن کاملMembranous Nephropathy: The Journey Continues …
With the discovery of the phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) as target antigens in 80% of patients with primary membranous nephropathy clinical and experimental research as well as patient management can be better adapted to the pathophysiology of the disease (Beck et al., 2009; Tomas et al., 2014). This is still not possible in the remaini...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2017
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfw404